Many thanks Mark, We are looking forward to your inspiring talk :-)
On 5/19/2012 12:04 AM, Mark Gerstein wrote:
> Molecular Networks: The Next-generation Annotation for Personal Genomes
> Mark Gerstein
> Yale University
> My talk will be concerned the analysis of networks and the use of
> networks as a "next-generation annotation" for interpreting personal
> genomes. I will initially describe current approaches to genome
> annotation in terms of one-dimension browser tracks. Then I will
> describe various aspects of networks. In particular, I will touch on
> the following topics: (1) I will show how analyzing the structure of
> the regulatory network indicates that it has a hierarchical layout
> with the "middle-managers" acting as information-flow bottlenecks and
> with more "influential" TFs on top. (2) I will show that most human
> variation occurs at the periphery of the network. (3) I will compare
> the topology and variation of the regulatory network to the call graph
> of a computer operating system, showing that they have different
> patterns of variation. (4) I will talk about web-based tools for the
> analysis of networks (TopNet and tYNA).
> Comparing genomes to computer operating systems in terms of the
> topology and evolution of their regulatory control networks.
> KK Yan, G Fang, N Bhardwaj, RP Alexander, M Gerstein (2010). Proc Natl
> Acad Sci U S A 107:9186-91.
> Analysis of diverse regulatory networks in a hierarchical context
> shows consistent tendencies for collaboration in the middle levels.
> N Bhardwaj, KK Yan, MB Gerstein (2010). Proc Natl Acad Sci U S A 107:6841-6.
> Positive selection at the protein network periphery: evaluation in
> terms of structural constraints and cellular context.
> PM Kim, JO Korbel, MB Gerstein (2007). Proc Natl Acad Sci U S A 104:20274-9.
> The tYNA platform for comparative interactomics: a web tool for
> managing, comparing and mining multiple networks.
> KY Yip, H Yu, PM Kim, M Schultz, M Gerstein (2006). Bioinformatics 22:2968-70.
Cathy H. Wu, Ph.D.
Edward G. Jefferson Chair of Bioinformatics& Computational Biology
Department of Computer& Information Sciences
Department of Biological Sciences
Director, Center for Bioinformatics& Computational Biology (CBCB)
Director, Master's Programs in Bioinformatics& Computational Biology
Director, Protein Information Resource (PIR)
Delaware Biotechnology Institute
University of Delaware
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