Yale U., New Haven, CT, USA
A central problem for 21st century science is annotating the human
genome and making this annotation useful for the interpretation of
personal genomes. My talk will focus on this problem. I will describe an
overall framework for data integration that brings together different
evidence to annotate features such as binding sites and ncRNAs. Much
of this work has been carried out within the ENCODE and modENCODE
projects, and I will describe my approach interchangeably both in
human and various model organisms (e.g. worm). I will further explain
how many different annotations can be inter-related to characterize
transcription in the intergenic space, build regulatory networks, and
identify fusion genes.
This work has clear implications for biomarker discovery.