Monday, June 28, 2021

SPN:

--
My dear friend. I am Abel Roberts, did you get my previous email?

Regards,
Abel Roberts

Tuesday, June 15, 2021

Fwd: Next week seminar.

Title:

Approaches to Genomic Privacy: Leakage Measurement, Data Sanitization
& Blockchain Storage

Abstract:

Functional genomics experiments on human subjects present a privacy
conundrum. On the one hand, many of the conclusions we infer from
these experiments are not tied to the identity of individuals but
represent universal statements about biology and disease. On the other
hand, the raw sequencing reads or the phenotypic information inferred
from these experiments can leak information about patients' variants,
presenting privacy challenges in terms of data sharing. There is a
great desire to share data as broadly as possible. Therefore,
measuring the amount of variant information leaked in various
experiments is a key first step in protecting private information. We
propose metrics to quantify private information leakage in functional
genomics data, linking attacks to validate the proposed metrics and
file formats that maximize the potential for data sharing while
protecting individuals' private information. Blockchain potentially
provides a way of storing genomic information and access to it
securely. We show how this can be done efficiently using various index
structures and how blockchain can be combined with our file formats
for sharing functional genomic information.
==

i0cdc

Saturday, June 12, 2021

HI

My name is Havilah Anthony, excuse me for bothering you but i have some important information's for you, so contact me back for more details thanks

Thursday, January 14, 2021

Re: [EXT] Abstract for MDACC Hogg seminar series

Title:

Analyzing the non-coding part of the cancer genome

Abstract:

My talk will focus on leveraging thousands of functional genomics
datasets to annotate the cancer genome and perform data mining to
discover cancer-associated regulators and variations.

First, I will go over the ENCODE annotations related to the cancer
genome. I will introduce our computational efforts to perform
large-scale integration to accurately define distal and proximal
regulatory elements (i.e., the MatchedFilter tool). Then I will show
how this extended gene annotation allows us to place oncogenic
transformations in the context of a broad cell space; here, many
normal-to-tumor transitions move towards a stem-like state, while
oncogene knockdowns show an opposing trend.

Next, I will look at our comprehensive regulatory networks of
transcription factors and RNA-binding proteins (TFs and RBPs). I will
showcase their value by highlighting how SUB1, a previously
uncharacterized RBP, drives aberrant tumor expression and amplifies
the well-known oncogenic TF MYC.

Third, I will introduce a workflow to prioritize key elements and
variants. I will showcase the application of this prioritization to
somatic burdening, cancer differential expression, and GWAS (the
LARVA, MOAT & uORF tools). Targeted validations of the prioritized
regulators, elements, and variants demonstrate the value of our
annotation resource.

Finally, I will describe how ENCODE annotations can be applied to the
comprehensive PCAWG mutation dataset. The goal is to determine the
overall burdening of various elements in cancer genomes. I will show
how this correlates with patient survival time and tumor clonality. I
adapt an additive-effects model from complex-trait studies to show
that putative passengers' aggregated effect, including undetected weak
drivers, provides significant additional power (~12% additive
variance) for predicting cancerous phenotypes beyond identified driver
mutations. Furthermore, this framework allows one to estimate
potential weak-driver mutations in samples lacking any
well-characterized driver alterations.

URLs:

http://encodec.encodeproject.org
http://radar.gersteinlab.org
http://MatchedFilter.gersteinlab.org
http://pcawg.gersteinlab.org

==
i0mda21

Wednesday, November 18, 2020

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Thursday, November 5, 2020

Fwd: CSHL Virtual Meeting: Biological Data Science

Topics in Precision Oncology

My talk will focus on leveraging thousands of cancer genomes and
functional genomics datasets to discover disease-associated regulators
and variations. First, I will go over the ENCODE annotations related
to the cancer genome. I will show these can be recast into a
comprehensive regulatory network of transcription factors and
RNA-binding proteins (TFs and RBPs). I will showcase the value of this
joint regulatory network by highlighting how SUB1, a previously
uncharacterized RBP, drives aberrant tumor expression and amplifies
the effect of the well-known oncogenic TF MYC. Next, I will describe
how ENCODE non-coding annotations can be applied to the comprehensive
PCAWG mutation dataset. The goal is to determine the overall burdening
of various elements in cancer genomes. I will show how this correlates
with patient survival time and tumor clonality. Finally, I adapt an
additive-effects model from complex-trait studies to show that the
aggregated effect of putative passengers, including undetected weak
drivers, provides significant additional power (~12% additive
variance) for predicting cancerous phenotypes, beyond identified
driver mutations. Furthermore, this framework allows one to estimate
potential weak-driver mutations in samples lacking any
well-characterized driver alterations.

https://meetings.cshl.edu/meetings.aspx?meet=data&year=20

i0bds20

Tuesday, September 22, 2020

Re: ENCODE Users meeting

Talk title:

Using ENCODE Data for Cancer Genomics

Abstract:

My talk will focus on leveraging thousands of functional genomics
datasets to annotate the cancer genome and perform data mining to
discover cancer-associated regulators and variations.

First, I will introduce our computational efforts to perform
large-scale integration to accurately define distal and proximal
regulatory elements (MatchedFilter) and then show how our extended
gene annotation allows us to place oncogenic transformations in the
context of a broad cell space; here, many normal-to-tumor transitions
move towards a stem-like state, while oncogene knockdowns show an
opposing trend.

Second, I will look at our comprehensive regulatory networks of
transcription factors and RNA-binding proteins (TFs and RBPs). I will
showcase their value by highlighting how SUB1, a previously
uncharacterized RBP, drives aberrant tumor expression and amplifies
the effect of the well-known oncogenic TF MYC.

Third, I will introduce a workflow to prioritize key elements and
variants. I will showcase the application of this prioritization to
somatic burdening, cancer differential expression, and GWAS (LARVA,
MOAT & uORF tools). Targeted validations of the prioritized
regulators, elements, and variants demonstrate the value of our
annotation resource.


URL:

http://encodec.encodeproject.org
http://radar.gersteinlab.org
http://MatchedFilter.gersteinlab.org

Venue:

ENCODE 2020 Users meeting

i0encusr