Sunday, March 18, 2018

Abstract for talk at McGill University, Human Genetics Seminar Series (*i0mcg18*)

Prioritizing Variants in Personal Genomes, with particular application to cancer


My talk will focus on prioritizing genetic variants associated with
cancer, to identify key variants driving cancer progression. First, I
will look at the overall functional impact of the variants in cancer
genomes, ranking them in terms of impact, for both coding and
non-coding regions. For the coding analysis, we use the ALoFT and
frustration tools, and for the noncoding analysis, we use FunSeq.
Then, I will look at the recurrence of variants within cancer cohorts.
Here we develop two approaches: one parametric (LARVA) and the other
non-parametric (MOAT). These both depend on background
mutation rate, which, in turn, is linked to genomic features such
as replication timing and TADs. I will discuss tools for analyzing these.
Finally, I will put all these methods together
through application to kidney and prostate cancers.

Tuesday, March 6, 2018

Indian Country Books / Native Media Network


Dear Educator / Communicator :

For the past several months Indian Country Books has been morphing into an interactive platform on Facebook and our web platform to produce, publish and distribute cultural and topical programs to our audience that is tethered to their cell phones.

Please take a look at some of the programming that we have posted on Facebook and archives on our platform at .
Our editorial policy is simple to show and illustrate the positive side and diversity of being Native.

We have experienced an exponential growth over the past several months, into the millions of views and viewers and look forward to serving Indian Country with high quality content accessible 24/7 on any web enabled device.

Please take a look at our broadcast channel:,
Our Archives:

And most of all our catalog of close to 10,000 titles for of and about Native America:

The sole support for our platform comes from the sale of books, so I would like to encourage you to purchase your books from us. "Rather than the other guys". 

Thank you
Harmon Houghton, Director of Programming
Native Media Network


Your $$$$ support means a lot to produce and publish authentic content


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