Thursday, October 4, 2012

2012 HUPO Abstract Entry Confirmation 294

Your abstract for the HUPO2012 conference was submitted on 5/3/2012.The log number for your abstract is 294.

Analysis of Protein Networks

Mark Gerstein

Yale Comp. Bio., New Haven, CT

Abstract

My talk will be concerned with understanding protein function on a genomic scale. My lab approaches this through the prediction and analysis of biological networks, focusing on protein-protein interaction and transcription-factor-target ones. I will describe how these networks can be determined through integration of many genomic features and how they can be analyzed in terms of various topological statistics. In particular, I will discuss a number of recent analyses: (1) Improving the prediction of molecular networks through systematic training-set expansion; (2) Showing how the analysis of biochemical pathways across environments potentially allows them to act as biosensors; (3) Analyzing the structure of the regulatory network indicates that it has a hierarchical layout with the "middle-managers" acting as information bottlenecks; (4) Integrating the protein-interaction network with molecular structures and motions; (5) Showing the some motions are conflicting with protein-protein interactions and (6) Creating practical web-based tools for the analysis of these networks (DynaSIN and tYNA).

 

networks.gersteinlab.org
dynasin.molmovdb.org 



Corresponding Author:
  Mark Gerstein
  Yale Comp. Bio.
  MBB
  PO Box 208114
  New Haven, CT 06520-8114
  United States
  2034328189
  Mark.gerstein@yale.edu


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