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Fwd: Confirmed - Keynote Speaker for Clinical Genomics Track at BioITWorld 2017 this May 23-25 in Boston

I discuss how we interpret and prioritize the many variants in a personal genome. I concentrate on rare and somatic variants and discuss ways of assessing their impact in coding regions using protein structure. For non-coding regions, I present ways to analyze the overall burden of mutations, finding allelic elements differentially affected by variants in paternal and maternal chromosomes and using network connectivity to prioritize variants.

65 word edit

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i0bioit17 

 

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We are pleased to announce a major upgrade  to our platform with the introduction of  our book Catalog  www.indiancountrybooks.com  with a listing of over 10,000 titles of Native American Art, Biography, Ceremony, Culture,  Folk lore, History, Sovereignty  and Tribal heritage & traditions.  The collection of books represents to most complete catalog dedicated to Indian country.

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Abstract for talk at UNC Charlotte (Nov. 2016)

TITLE:

Personal Genomics

ABSTRACT:

My talk will focus on a variety of topics in personal genomics,
principally on how we interpret and prioritize the many variants in a
personal genome. I will concentrate on rare and somatic variants. I
will discuss a number of ways of assessing their impact in coding
regions using protein structure (via looking for cryptic allosteric
sites and regions of change in frustration). For non-coding regions,
I will present ways to analyze the overall burden of mutations,
finding allelic elements differentially affected by variants in
paternal and maternal chromosomes and using network connectivity (eg
hubs) to prioritize variants. Throughout the talk I will highlight a
number of practical software tools that we have developed for
prioritization, including: FunSeq.gersteinlab.org,
AlleleDB.gersteinlab.org, STRESS.gersteinlab.org and
Networks.gersteinlab.org . I will also motivate the talk a bit by
discussing why prioritization is useful in the context of rapidly
increasing amounts of genome sequences.

REFS

http://papers.gersteinlab.org/papers/alleledb
http://papers.gersteinlab.org/papers/stress
http://papers.gersteinlab.org/papers/costseq2
http://papers.gersteinlab.org/papers/larva
http://papers.gersteinlab.org/papers/music
http://papers.gersteinlab.org/papers/funseq
==

i0uncc16

Fwd: Abstract for talk at Ohio State for BMI seminar series (Oct. 2016)

Personal Genomics

My talk will focus on a variety of topics in personal genomics,
principally on how we interpret and prioritize the many variants in a
personal genome. I will concentrate on rare and somatic variants. I
will discuss a number of ways of assessing their impact in coding regions
using protein structure (via
looking for cryptic allosteric sites and regions of regions great
change in frustration).
For non-coding regions, I will present ways to analyze
the overall burden of mutations, finding allelic elements
differentially affected by variants in paternal and maternal alleles
and using network connectivity (eg hubs) to prioritize variants.
Throughout the talk I will
highlight a number of practical software tools that we have developed
for prioritization, including: FunSeq.gersteinlab.org ,
AlleleDB.gersteinlab.org, STRESS.gersteinlab.org and
Networks.gersteinlab.org . I will also motivate the talk a bit by
discussing why prioritization is useful in the context of rapidly
increasing amounts of genome sequences.

==
i0os16

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Abstract for talk at Penn Bioinformatics Forum (Sep. 2016)

Personal Genomics

My talk will focus on a variety of topics in personal genomics,
principally on how we interpret and prioritize the many variants in a
personal genome. I will concentrate on rare and somatic variants. I
will discuss a number of ways of assessing their impact in coding regions
using protein structure (via
looking for cryptic allosteric sites and regions of regions great
change in frustration).
For non-coding regions, I will present ways to analyze
the overall burden of mutations, finding allelic elements
differentially affected by variants in paternal and maternal alleles
and using network connectivity (eg hubs) to prioritize variants.
Throughout the talk I will
highlight a number of practical software tools that we have developed
for prioritization, including: FunSeq.gersteinlab.org ,
AlleleDB.gersteinlab.org, STRESS.gersteinlab.org and
Networks.gersteinlab.org . I will also motivate the talk a bit by
discussing why prioritization is useful in the context of rapidly
increasing amounts of genome sequences.

==
i0pbf