I discuss how we interpret and prioritize the many variants in a personal genome. I concentrate on rare and somatic variants and discuss ways of assessing their impact in coding regions using protein structure. For non-coding regions, I present ways to analyze the overall burden of mutations, finding allelic elements differentially affected by variants in paternal and maternal chromosomes and using network connectivity to prioritize variants.
65 word edit
65 word edit
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i0bioit17
i0bioit17
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