Tuesday, June 28, 2016

Abstract & Title for talk at Royal Holloway, University of London (July 2016)

Personal Genomics

My talk will focus on a variety of topics in personal genomics,
principally on how we interpret and prioritize the many variants in a
personal genome. I will concentrate on rare and somatic variants. I
will discuss a number of ways of getting at their impact including
looking for cryptic allosteric sites in coding regions, analyzing the
burdening in non-coding regions, finding allelic elements
differentially affected by variants in paternal and maternal alleles
and using network connectivity (eg hubs). Throughout the talk I will
highlight a number of practical software tools that we have developed
for prioritization, including: FunSeq.gersteinlab.org ,
AlleleDB.gersteinlab.org, STRESS.gersteinlab.org and
Networks.gersteinlab.org . I will also motivate the talk a bit by
discussing why prioritization is useful in the context of rapidly
increasing amounts of genome sequences.


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