Monday, March 25, 2013

Abstract for talk i0cmg - Comp_Meth_Prioritizing_Var_Exome_Seq_Pgenes_trueLoF_nethubs--20130319-i0cmg

* Filtering out Artifacts Due to Pseudogenes
-Certain genes have lots of similar pseudogenes
which could confound variant calling

* Finding True LoF Mutations
-Not just stop codon finding: tricky if one takes into
account splicing, NMD, indels, &c

* Using High Network Connectivity
-More connected genes in many networks have a
greater chance of being disease causing

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