Sunday, January 29, 2012

Re: abstract for talk at Berkeley Statistics and Genomics Seminar 16-Feb-2012 ((* i0sf12 *))

Thanks Mark. I look forward to seeing you on February 16th.


Sent from my iPhone

On Jan 29, 2012, at 21:03, Mark Gerstein <> wrote:

> Approaches to Genome Annotation
> Mark Gerstein
> Yale U., New Haven, CT, USA
> A central problem for 21st century science is annotating the human
> genome and making this annotation useful for the interpretation of
> personal genomes. My talk will focus on annotating the bulk of the
> genome that does not code for canonical genes, concentrating on
> intergenic features such as TF binding sites, non-coding RNAs
> (ncRNAs), and pseudogenes (protein fossils). I will describe an
> overall framework for data integration that brings together different
> evidence to annotate features such as binding sites and ncRNAs. Much
> of this work has been carried out within the ENCODE and modENCODE
> projects, and I will describe my approach interchangeably both in
> human and various model organisms (e.g. worm). I will further explain
> how many different annotations can be inter-related to characterize
> the intergenic space, build regulatory networks, and construct
> predictive models of gene expression from chromatin features and the
> activity at binding sites.

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