Best,
Sandrine
Sent from my iPhone
On Jan 29, 2012, at 21:03, Mark Gerstein <Mark.Gerstein@yale.edu> wrote:
> Approaches to Genome Annotation
>
> Mark Gerstein
>
> Yale U., New Haven, CT, USA
>
> A central problem for 21st century science is annotating the human
> genome and making this annotation useful for the interpretation of
> personal genomes. My talk will focus on annotating the bulk of the
> genome that does not code for canonical genes, concentrating on
> intergenic features such as TF binding sites, non-coding RNAs
> (ncRNAs), and pseudogenes (protein fossils). I will describe an
> overall framework for data integration that brings together different
> evidence to annotate features such as binding sites and ncRNAs. Much
> of this work has been carried out within the ENCODE and modENCODE
> projects, and I will describe my approach interchangeably both in
> human and various model organisms (e.g. worm). I will further explain
> how many different annotations can be inter-related to characterize
> the intergenic space, build regulatory networks, and construct
> predictive models of gene expression from chromatin features and the
> activity at binding sites.
>
> URLS:
>
> http://pseudogene.org
> http://GenomeTECH.Gersteinlab.org
