Abstract for talk at McGill University, Human Genetics Seminar Series (*i0mcg18*)

Title:
Prioritizing Variants in Personal Genomes, with particular application to cancer

Abstract:

My talk will focus on prioritizing genetic variants associated with
cancer, to identify key variants driving cancer progression. First, I
will look at the overall functional impact of the variants in cancer
genomes, ranking them in terms of impact, for both coding and
non-coding regions. For the coding analysis, we use the ALoFT and
frustration tools, and for the noncoding analysis, we use FunSeq.
Then, I will look at the recurrence of variants within cancer cohorts.
Here we develop two approaches: one parametric (LARVA) and the other
non-parametric (MOAT). These both depend on background
mutation rate, which, in turn, is linked to genomic features such
as replication timing and TADs. I will discuss tools for analyzing these.
Finally, I will put all these methods together
through application to kidney and prostate cancers.

Indian Country Books / Native Media Network

 

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INVESTMENT/BUSINESS PARTNERSHIP.

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please see the link below:


https://www.nytimes.com/2014/10/19/business/of-virtue-and-vice-and-a-vatican-priest.html


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priest Nunzio Scarano